Accueil / Publications / Journal of Photochemistry & Photobiology, B: Biology Blue light: Friend or foe ? (Mars 2023)
Journal of Photochemistry & Photobiology, B: Biology Blue light: Friend or foe ? (Mars 2023)
Journal of Photochemistry & Photobiology, B: Biology
Blue light: Friend or foe ?
Blue light: Friend or foe ?
Magali Bonnans, Linda Fouque, Michèle Pelletier, Rachel Chabert, Sandrine Pinacolo, Laura Restellini, Karine Cucumel
Background: The purpose of this study was to elucidate why some potentially damaging and beneficial effects
were obtained following blue light exposures on skin.
Materials and Methods: Light-emitting diode (LED) devices containing 415 and 470 nm bulbs were used on
normal human keratinocytes, skin biopsies and subjects with acne. Reactive oxygen species (ROS) evaluation
was performed after a course of blue LED light exposures. A comparison between very small bandwidth centered
at 415 nm and a combination of (415 + 470 nm) wavelengths was also carried out regarding the effects on ROS
production. The effects on other targets such as opsin1 short wavelength (OPN1 SW) photoreceptor, fibrillin-1
dermal component, LL37 antimicrobial peptide and interleukin-8 (IL-8) proinflammatory cytokine were then
explored. Finally, clinical pictures of acne signs were also investigated after blue LED exposures.
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